Endocrine Abstracts

The calcium-sensing receptor (CaR) is the key controller of parathyroid hormone (PTH) secretion and extracellular calcium homeostasis. Hyperphosphataemia increases PTH secretion and is associated with secondary hyperparathyroidism (SHPT). We reported recently that inorganic phosphate (Pi), and sulphate, can attenuate CaR activity directly (in CaR-transfected HEK-293 cells) and Pi can increase PTH secretion rapidly from human and murine parathyroid cells. To investigate this fu...